"In this high-risk population with relapsed and refractory disease and extensive prior therapy, pirtobrutinib demonstrated ...

We harnessed two single-cell multiomics methods to characterize the heterogeneity of acute myeloid leukemia with complex karyotype (CK-AML). Our data link genetic, non-genetic and functional ...

Cases of PCL are usually associated with complex karyotypes and lack of CD56 expression. PCL cases are frequently associated with 14q32 translocations, the most common being CCND1(11q13).