重要突破！南大团队发现强效HIV纳米抗体
近年来，抗逆转录病毒疗法（ART）在抑制HIV复制方面取得了显著进展，显著延长了艾滋病患者的寿命，但该疗法同时也带来了严重的副作用，并导致大量耐药病例的出现。CD4作为HIV进入宿主细胞的主要受体，一直是HIV药物研发的重点靶点。然而，目前唯一的CD ...
上科大白芳AS: 构象系综增强的通用分子表征推动基于配体的药物发现
创新点： 上海科技大学白芳团队通过分子间对比学习策略，将分子构象空间的系综信息引入分子表征模型，使得虚拟筛选、靶标鉴定、分子属性预测等下游任务性能得到显著提升，推动了通用分子表征方法的发展。
Researchers uncover key insights into cholesterol's structure in cell membranes
A new study by Rice University researchers led by Jason Hafner could open new pathways for understanding how cholesterol ...
南京大学团队发现强效HIV纳米抗体，对艾滋病临床治疗意义重大
近年来，抗逆转录病毒疗法（ART）在抑制HIV复制方面取得了显著进展，显著延长了艾滋病患者的寿命，但该疗法同时也带来了严重的副作用，并导致大量耐药病例的出现。CD4作为HIV进入宿主细胞的主要受体，一直是HIV药物研发的重点靶点。然而，目前唯一的CD4抗体药物在抑制HIV病毒的广谱性和效率上仍存在不足，长期应用会导致耐 ...
DNA origami and fluorescent probes can precisely release molecular cargo
In the world of nanotechnology, the development of dynamic systems that respond to molecular signals is becoming increasingly ...
Physicists achieve high selectivity in nanostructures using selenium doping
Physicists from the National University of Singapore (NUS) have achieved controlled conformational arrangements in ...
C&EN4 天
Eusebio Juaristi has spent a career thinking about molecules in 3D
Eusebio Juaristi stands up in the middle of our conversation and returns with a bag full of colorful plastic sticks. By ...
technologynetworks1 天
Researchers Visualize the Structure of Cholesterol in Cell Membranes for the First Time
Researchers used Raman spectroscopy to study cholesterol in cell membranes, discovering unique structural variations. This ...
Science Daily6 天
Nanotechnology: DNA origami with cargo function
LMU chemists present two studies that open up new possibilities for biotechnological applications.
High speed atomic force microscopy studies provide insights into influenza A viral replication
Previous attempts to understand what possible conformational changes occur during Influenza A viral multiplication cycle had ...