During DNA replication, the unwinding of strands leaves a single strand vulnerable. How does the cell protect these strands from damage? How would you identify the protein that serves as a ...

The first section of the book, Cellular DNA Replication, begins with an excellent overview of genome duplication by Thomas J. Kelly and Bruce Stillman, followed by chapters on specific steps in ...

随后研究团队研究发现抑制RF-RDs会导致复制叉新生DNA的降解，并显著增加DNA末端切割和DNA断裂的发生。进一步体外生化实验和细胞实验表明，RF-RDs能够抑制核酸酶DNA2的核酸酶活性，从而减缓DNA2对复制叉的降解。研究团队进一步通过全基因组 ...

Original DNA template - DNA is a double helix made of two complementary strands. Each strand can be used as a template to create a new DNA molecule. Free DNA nucleotides – needed to form the new ...

At the 8-cell stage of mouse embryo development, the coordination between DNA unwinding and replication appears to improve. © ...

Single-cell analysis has helped researchers uncover how BKPyV replicates, opening the door to new drug targets.

The study is published in the journal PLOS Pathogens. With only seven genes, the BK polyomavirus must use the host cell’s DNA replication machinery to produce new viruses. Although the virus was ...

This process is essential for the proper functioning and survival of all living organisms. DNA replication is the process by which the DNA molecule makes an exact copy of itself during cell division.

The study is published in the journal PLOS Pathogens. With only seven genes, the BK polyomavirus must use the host cell's DNA replication machinery to produce new viruses. Although the virus was ...

as well as for DNA replication, repair, and segregation to daughter cells. Nucleosomes are repetitive building blocks ...

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on ...

We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated ...