总的来说，本研究证明了FTO介导的病理过程在具有侵袭性生长激素分泌的垂体神经内分泌肿瘤中的重要性，并揭示了新的治疗靶点。此外，由FTO调节的连接复合体相关基因可以作为分类生长激素分泌垂体神经内分泌肿瘤的创新因子。

The genome of the immature primordial germ cells of the developing embryo (zygote and blastomeres) undergoes extensive demethylation allowing for totipotency while erasing methylation marks ...

Similarly, the memory suppressing gene PP1is rapidly methylated and deactivated 4. Whatever the mechanisms, it seems that active demethylation can play a role in a neuron’s return to basal gene ...

The sequencing of the human genome at the turn of the 21st century was heralded as a monumental scientific achievement ...

For human tissues, prior experimental manipulations are impractical, and genomic alterations are employed. Somatic mutations mark subclones and their fates can be reconstructed with DNA sequencing ...

They found that ischemic injury induces astrocytes to modify their methylome to a stem cell state, involving the methylation ...

Samples from 15 patients also showed that demethylation had occurred in tumours after treatment, while RNA analysis confirmed that inflammation was taking place in the tumour that wasn’t present ...

Diverse frequencies among individuals from various racial and ethnic backgrounds can result in modified therapeutic strategies. Whereas the CYP2D6*4 allele is present at a high frequency in ...

KEY POINTS A 65-year-old woman presented to the emergency department with an 8-day history of progressive leg weakness and ...

Mission Statement: Evidence-based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research ...