Dysregulation of phosphorylation and dephosphorylation events is associated with several diseases and malignancies in humans. The determinants of specificity for kinases are not well understood ...

The phosphorylation of the endogenous protein in cells should decrease in response to one or more signals that are known to inhibit GSK3. Dephosphorylation should occur with similar kinetics to ...

An important feature of these networks is the multiple reversible reactions of protein phosphorylation (catalyzed by protein kinases) and dephosphorylation (catalyzed by protein phosphatases). Protein ...

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DEPTAC. Based on PROTACs, or protein-targeting chimeras, D20, a dephosphorylation-targeting chimera, delivers PP1 to tau. The C-terminal tail (gray) helps the construct enter cells. [Courtesy of Xiao ...

"Many cell proteins are activated by the attachment of phosphate groups in a process known as phosphorylation. With BAG3, ...

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In analyzing BAG3 activation more closely, the researchers were surprised at what they observed. "Many cell proteins are activated by the attachment of phosphate groups in a process known as ...

When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works. As our reviews explain, we were impressed with both consoles at launch, and over the last ...