文章中，研究者发现，人类骨髓衍生的间充质干细胞（hMSCs）或能帮助治愈肠道内壁并促进积极的免疫反应，这些影响是研究人员在施用干细胞后早期注意到的，并且在没有活的hMSCs存在时影响会持续存在。克罗恩病是一种能引起机体胃肠道慢性炎症的炎性肠病，其被认 ...

原发性硬化性胆管炎(Primary Sclerosing Cholangitis，PSC)是一种慢性胆汁淤积性肝病，其特征是胆管炎症和纤维化导致的胆管狭窄，最终可进展为肝硬化、肝衰竭。

GlobalData’s report assesses the drugs in the Bile Acid Receptor pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

xenobiotic compounds and microbial byproducts can maintain critical gut immunity by inducing antimicrobial gene expression. FXR: Farnesoid X receptor; VDR: Vitamin D receptor; RXR: Retinoid X ...

Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease ...

The sequence homology across the nuclear receptor superfamily indicates that these receptors evolved through divergent evolution 5, but gives no information about the role of ligands in the ...

Our lab identified that excessive copper concentrations decreased metabolic nuclear receptor activity (FXR - farnesoid X receptor, HNF4a – hepatocyte nuclear factor, and LRH-1 – liver receptor homolog ...

Therapeutic strategies targeting this pathway include peroxisome proliferator-activated receptor (PPAR) agonists, bile acid-farnesoid X receptor (FXR) agonists, and de novo lipogenesis (DNL ...

Ocaliva is a potent and selective agonist of the farnesoid X receptor (FXR), which is expressed at high levels in the liver and intestine and thought to be a key regulator of bile acid ...

Removing a nuclear bile acid receptor that regulates glucose and lipid stability from the intestine blocks gut inflammation in mice, according to researchers at Children's Hospital Los Angeles.

When NR1H4/FXR, a nuclear receptor, does not function appropriately in NASH, it can result in bile acid-related liver damage and inflammation. GLP-1R issues in NASH can lead to insulin resistance ...