With this knowledge, scientists are seeking to better understand the role of GPCRs in islet biology and hormone secretion, and how signaling in the cell through these receptors is disrupted in ...

As the largest family of cell surface receptors, GPCRs account for over one-third of drug screening efforts. Inositol-1-phosphate (IP1) is a metabolite of Gq signaling and has been shown to be very ...

To better understand mechanisms of GPCR activation, this information must be complemented by knowledge of dynamic signaling pathways connecting drug-binding sites to the intracellular surface. Here we ...

Exicure, Inc. (Nasdaq: XCUR, “Exicure”, “the Company”), has announced the signing of a Memorandum of Understanding (MOU) with ...

Researchers at the University of Chicago have successfully captured detailed images of adhesion G protein-coupled receptors, ...

We also develop phototropin and cryptochrome-based optogenetic tools for regulating G protein signaling independent of GPCRs. These engineered tools allow the acquisition of dynamic molecular pictures ...

Poltavets, Valentina Faulkner, Jessica W. Dhatrak, Deepak Whitfield, Robert J. McColl, Shaun R. and Kochetkova, Marina 2021. CXCR4-CCR7 Heterodimerization Is a Driver ...

Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with each ...

Bruker announces the acceptance of a 1.2 GHz Ascend™ Nuclear Magnetic Resonance (NMR) spectrometer at the Swiss High-field ...