Direct evidence for GPCR heterodimerization came from studies with non-functional GABA B receptors that dimerize to generate a functional receptor. Recent studies have also provided direct ...

Cell surface GABA type A receptors (GABA A Rs) undergo endocytosis and trafficking to lysosomes for degradation; however, the proteins responsible for driving the retrograde transport of these ...

Brohan, Janette and Goudra, Basavana G. 2017. The Role of GABA Receptor Agonists in Anesthesia and Sedation. CNS Drugs, Vol. 31, Issue. 10, p. 845. This concise, evidence-based board review book, ...

Nutraceuticals offer potential health benefits, from migraine relief to cognitive support, but safety and regulatory issues ...

to specifically target the α5 subunit of GABA-A receptors in Ts65Dn mice, a classical animal model of DS. They found that the drug had no convulsant effects and did not promote any side effects ...

These sleeping pills work on the GABA receptors in the brain, which help control our level of alertness or relaxation. The selective GABA medications target only a certain type of GABA receptor ...

Attachment to the specific binding site enhances the affinity of GABA for its receptor site on the same receptor complex. The pharmacodynamic consequences of benzodiazepine agonist actions include ...