These sleeping pills work on the GABA receptors in the brain, which help control our level of alertness or relaxation. The selective GABA medications target only a certain type of GABA receptor ...

Nutraceuticals offer potential health benefits, from migraine relief to cognitive support, but safety and regulatory issues ...

to specifically target the α5 subunit of GABA-A receptors in Ts65Dn mice, a classical animal model of DS. They found that the drug had no convulsant effects and did not promote any side effects ...

Direct evidence for GPCR heterodimerization came from studies with non-functional GABA B receptors that dimerize to generate a functional receptor. Recent studies have also provided direct ...

Transient lower esophageal sphincter relaxation inhibitors such as GABA type B agonists and mGluR5 inhibitors have been shown to decrease GERD episodes and improve reflux-related symptoms.

Cell surface GABA type A receptors (GABA A Rs) undergo endocytosis and trafficking to lysosomes for degradation; however, the proteins responsible for driving the retrograde transport of these ...

Subtle activation of a small subset of neurons in one region of the brain can make male mice resilient to, and even reverse, the detrimental effects of chronic stress. The same is true for female mice ...

Attachment to the specific binding site enhances the affinity of GABA for its receptor site on the same receptor complex. The pharmacodynamic consequences of benzodiazepine agonist actions include ...