Cluster numbers are shown with corresponding germ layers, organs, and tissues. This figure shows that for examples cells of cluster 8 comprise apical plate and cells of cluster 9 comprise coelom ...

Accumulating evidence indicates that epigenetic modifiers have key roles in genome-wide reprogramming and activation and repression of specific genes during mammalian germ-cell development.

Two weeks after a human egg is fertilized, primordial germ cells (PGCs), which develop into sperm and eggs, are formed. In six to 10 weeks after fertilization, PGCs differentiate into pro ...