Furthermore, there is a huge shortage of liver donors. A more recent approach is transplantation of mature liver cells, known as hepatocytes. “The problem is obtaining sufficient quantities of ...

[47,48] However, recent work with hepatocyte transplantation has demonstrated the capability of adult hepatocytes to proliferate much more extensively. [49] In several animal models, it was shown ...

In summary, ES cells could be regarded as a prospective and unlimited source for hepatocyte transplantation and gene therapy. However, there is more than one hurdle that needs to be overcome ...