Children who have two or more persistent islet autoantibodies are at high risk; 70% of them will progress to diabetes in <10 years. [4] In contrast, children with a single positive persistent ...

Blood samples will be taken to investigate whether the study drug has induced a protective immune response to insulin. Depending upon the outcome of Pre-POINT, the study will continue to the Phase II ...

Autoantibodies to insulin (IAAs), GAD65 (GADAs), insulinoma-associated protein 2 (IA2As), and ZnT8 (ZnT8As) were measured with radioimmunoassays. The primary outcome for this autoantibody analysis ...

This was concomitant with an increase in germinal center B cells and augmented insulin autoantibody production. The effect of PD-1 blockade on germinal centers was reduced when mice were treated with ...