The cause of Alzheimer's disease still remains a mystery among researchers. Alzheimer's is the most common form of dementia, ...
【导读】头颈部鳞状细胞癌(HNSCC)是一种极具侵袭性的疾病,其特征在于肿瘤免疫微环境(TIME)的异质性。肿瘤相关巨噬细胞(TAMs)构成了TIME 中的主要先天免疫群体,在恶性肿瘤进展中参与了关键的调节过程。SPP1 + 巨噬细胞(SPP1 + ...
The etiology of many chronic diseases caused by chronic inflammation includes dysregulation of the pro-inflammatory cytokines IL-1β and IL-18. Therapeutic strategies developed to date have ...
Inflammasomes activate the protein-cleaving enzyme caspase 1, which leads to the release of two strong pro-inflammatory molecules, interleukin-1β (IL-1β) and IL-18. Caspase 1 also cleaves the ...