T helper 17 (Th17) cells generate the pro-inflammatory ... To signal through the receptor complex constituted of the subunits of IL17RA and IL17RC, IL17 and IL17F form homodimers and heterodimers ...

This effort was derailed by unsettling results from experiments in which her team implanted tumours in recipient animals with deletion of the gene encoding the primary receptor for IL-17.

The results of two new studies suggest mutations in the gene encoding the interleukin (IL)-1 receptor antagonist (IL-1Ra) are responsible for a spectrum of childhood inflammatory disorders ...