The most common nonfamilial forms of amyloidosis that involve the kidney are the AL (amyloid light chain) and AA (serum amyloid A) types. These two forms require different treatment strategies ...

AL (immunoglobulin light chain) amyloidosis is a rare disease that often results in progressive organ dysfunction, organ failure and eventual death. Clonal plasma cells in the bone marrow secrete ...

Ingrid Haas (BZH, Heidelberg) presented data implicating mannose trimming in the proteasome-mediated degradation of an immunoglobulin κ-light-chain engineered to contain one or two glycosylation ...

Lisaftoclax is under clinical development by Ascentage Pharma Group International and currently in Phase II for Solid Tumor.