Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity ...
Researchers have developed lipid nanoparticles (LNPs) that cross the blood-brain barrier (BBB) and precisely target brain cells, a major step toward treating neurological diseases like Alzheimer’s.
Local delivery of mRNA-based immunotherapy represents an option for cancer therapy. Here the authors report that intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21 ...
This makes the development of reliable delivery methods essential for the future success of mRNA immunotherapies ... against degradation during their intratumoral administration.
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Potential new mRNA-based therapy for pre-eclampsiaThis formulation demonstrated enhanced mRNA delivery to the placenta using a β2-glycoprotein I (β2-GPI)-based targeting ...
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Novel mixture of mRNA in nanoparticles show therapeutic potential against tumor progressionMore information: Ahmed E. I. Hamouda et al, Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity, Nature ...
Note to the editor Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity. Hamouda et al. Nature Communications ...
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