Malignant cells down-regulate cell death by overexpressing a transcription factor called BCL6. “Our idea was to borrow a little bit of the activity of the kinase and drag it over to where BCL6 is ...

Oncodesign Precision Medicine (OPM) (ISIN: FR001400CM63; Mnemonic: ALOPM), a biopharmaceutical company specializing in ...

在这项研究中，研究人员报道了铜绿假单胞菌中的丝状温和噬菌体携带的三组分毒素-抗毒素系统KKP（kinase-kinase-phosphatase）的双重功能。原噬菌体诱导通常通过控制噬菌体阻遏蛋白活性进行调节，例如宿主因子对阻遏蛋白的特异性切割使其失 ...

剔除这种酶能减少心脏 功能障碍 ...

Trethera Corporation (“Trethera”), a clinical stage biopharmaceutical company committed to developing novel drugs targeting ...

Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to ...

Researchers at Baylor College of Medicine and Deliver Therapeutics Inc. have synthesized protein kinase inhibitors reported to be useful for the treatment of cancer and psoriasis.

洛拉替尼助力患者走向临床治愈：对于ALK阳性晚期NSCLC一线治疗，临床医生应基于国内外权威指南，综合考量药物的疗效和安全性，以及患者的疾病特征、ECOG PS评分、患者意愿和家庭经济条件等因素，做出恰当的选择。洛拉替尼具有独特大环结构，更容易穿透血脑屏障，可广泛覆盖、强效抑制ALK已知耐药突变，在CROWN研究中获得目前最长研究者（INV）评估mPFS（95% ...

Systemic JAK inhibitor therapy with tofacitinib was associated with the most favorable outcomes among patients with extensive vitiligo.

A group has found that heart fibrosis is regulated by the enzyme protein kinase N (PKN). As there are no therapies targeting PKN, controlling this enzyme is a promising therapeutic target to ...

Biotechnology Co. Ltd. has disclosed proteolysis targeting chimeras (PROTACs) comprising a cereblon (CRBN) ligand coupled to a mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; HPK1; ...