Translocations, in genetics ... Many important clinical conditions like Down syndrome and chronic myelogenous leukemia result from translocation mutations. A change in chromosome structure ...

Figure 2 shows an example of a spectral karyotype prepared from acute myeloid leukemia cells with multiple translocations, which are indicated by arrows. The image obtained in the microscope ...

Metaphase cells from an untreated acute myelogenous leukemia (AML ... In this cell, rearrangements are caused by translocations (t), deletions (del), or dicentric chromosomes (dic).

Cite this: Recent Advances in the Biology and Management of Primary Acute Myeloid Leukemia with Rearrangements of the MLL Gene - Medscape - May 03, 2000. Strout, MP, Caligiuri, MA, Bloomfield CD.

The number of chromosomal alterations observed in AML [2,3] (more than 200 translocations, in addition to several point mutations) is enormous and makes it impossible to screen each one of them as ...