What additional lessons can be learned? Is MYC stability altered at specific subcellular locales, or when in partnership with certain DNA, RNA or protein molecules, or as a mechanism to regulate ...

That's because mis-regulation of Myc proteins is a hallmark of cancer and N-Myc plays a key role in childhood brain cancers. "Because Aurora-A stabilizes N-Myc against degradation, inhibiting the ...

That's because mis-regulation of Myc proteins is a hallmark of cancer and N-Myc plays a key role in childhood brain cancers. "Because Aurora-A stabilizes N-Myc against degradation, inhibiting the ...

A new approach to targeting a protein involved in cell division, which can misfunction in cancer, has revealed new insights into how it functions. The protein, called Aurora-A, is one of a group of ...

In this manuscript, Yao et al. present solid evidence to show that MnMYL3 may serve as a receptor for NNV via macropinocytosis. This manuscript is valuable for understanding the molecular mechanisms ...

MRT-2359. That program is MRT-2359, an oral MGD designed to target translation termination factor protein GSPT1 for the treatment of MYC oncogene-driven tumors, including metastatic non-small cell ...

"p14 ARF is normally expressed at very low levels in healthy cells, but increased expression is induced in response to oncogenic stress, such as upregulation of MYC or other oncogenes," explains ...