Baylor College of Medicine4y
Aortic Valve Operative Outcomes in Marfan Patients
At this time, recruitment for extended follow-up is complete. Manifestations of the Marfan syndrome appear in many parts of the body, especially in the bones and ligaments (the skeletal system), the ...
Hosted on MSN28d
Scientists identify a probable contributor to weakness of the aorta in people with genetic disorder
Marfan syndrome's features were systematically described ... "The new findings could help us better understand why the aortic root is likely to dilate in patients with Loeys-Dietz syndrome ...
Frontiers13h
Advances in molecular genetics of Marfan syndrome and related disorders
Marfan syndrome (MFS) is a heritable multisystemic disorder with a spectrum of clinical manifestations primarily linked to variants in the Fibrillin-1 ...
Nature5y
Effectiveness of ACE inhibition in patients with Marfan's syndrome on β-blockade
The standard treatment for the connective tissue disorder Marfan's syndrome (MFS) is β-blockade, aimed at reducing aortic wall stress. Angiotensin II type 1 and 2 receptors (AT 1 and AT 2 ...
Nature4d
Extracellular control of TGFβ signalling in vascular development and disease
Transgenic mouse models of Marfan syndrome exposed a surprising and crucial function of elastic extracellular matrix components in regulating TGFβ signalling. By interacting with unprocessed ...