HSF1 transiently accumulates in the nucleus of human monocytes undergoing macrophage differentiation, including M-CSF-treated peripheral blood monocytes and phorbol ester-treated THP1 cells.

The monocyte effect. Monocytes/macrophages (promonocytes in the bone marrow, circulating monocytes, tissue macrophages) play a major role in the induction and regulation of immune reactivity.

The following is a summary of “Elevated Fcy receptor expression augments pro-inflammatory macrophage phagocytosis in systemic ...

Macrophages eat other cells and are able to pull apart their proteins in order to ... Raveney, B. J. E., and Munder, M. (2009) Monocyte dependent regulation of autoimmune inflammation.

Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse ...

The stressed macrophages then send out an "SOS" signal by releasing a substance called MCP-1 (monocyte chemoattractant ...

Sergio A. Giralt, MD, discusses how the pathophysiology of chronic graft-vs-host disease involves complex immune dysregulation, with CSF1R playing a crucial role in driving the differentiation of ...

We were also the first to report that tumor growth induces monocyte-derived tumor-associated macrophages (TAMs) supported by juxtacrine Notch signaling by cancer cells. We found that TAMs can be ...