Now, the combination of bupropion and naltrexone is being studied for possible weight-loss effects through its synergistic action on appetite signaling and the mesolimbic reward system.

The campaign inspires individuals to seek help in taking control of their weight-loss efforts with CONTRAVE, an established ...

Naltrexone is an opioid antagonist approved for alcohol misuse disorder. Nadolsky said it blocks the negative endorphin feedback, and this blocking helps to amplify the benefits of bupropion.

The naltrexone/bupropion combination has yet to gain FDA or EMA approval as concern remains regarding CV safety. The combination is seen to eliminate or attenuate the decreases in blood pressure ...

Some of the strongest weight loss pills available today include: In clinical trials, roughly half of people taking naltrexone/bupropion lost at least 5% of their body weight within one year.