For people living with narcolepsy, no amount of sleep alleviates the feeling of being tired. While most people are either awake or asleep, narcolepsy feels as if you're never really in either state.

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In addition to excessive daytime sleepiness, up to 60% of narcolepsy cases include cataplexy, which is a sudden loss of muscle control. When patients experience intense emotion, either positive or ...

Gelastic cataplexy is a sudden loss of muscle tone without loss of consciousness triggered by laughter. It’s a characteristic sign of a rare genetic disease called Niemann Pick disease type C.

ENCORE was a multi-center, two-period Phase 3 trial evaluating the long-term efficacy and safety of AXS-12 in patients with narcolepsy with cataplexy, consisting of a 6-month open-label AXS-12 ...

Samelisant (SUVNG-3031) is under development for the treatment of narcolepsy with and without cataplexy and cognitive disorders. The drug candidate is administered orally in the form of tablet. The ...

On October 16, 2024, LUMRYZ was additionally approved as a once-at-bedtime treatment for cataplexy or EDS in patients 7 years of age and older with narcolepsy. The FDA approval of LUMRYZ was supported ...

Axsome Therapeutics has announced that its investigational narcolepsy therapy has met the primary endpoint in a Phase III trial. AXS-12 (reboxetine), the norepinephrine reuptake inhibitor and ...

There are two types of narcolepsy, and both cause EDS. Most people with Type 1 (with cataplexy — the sudden loss of muscle tone explained above) have low levels of the brain hormone hypocretin ...