2018). These knock-in (KI) mice carry a serine to alanine mutation (S65A) in the N-terminal ubiquitin-like domain of the Park2 gene that encodes Parkin, a ubiquitin E3 ligase (McWilliams et al., 2018) ...

Several lines of evidence indicate that PINK1 can protect cells from different types of stress, including proteasomal inhibition, oxidative stress, mitochondrial blockers and apoptotic inducers.

PINK1 and Parkin are two key genes involved in mitophagy, and mutations in these genes are linked to early-onset Parkinson's disease. Until the discovery of two proteins, NAP1 and SINTBAD ...

Parkin, PINK1 and DJ-1 operate in the same pathway; they can interact to create an ubiquitin–protein ligase complex. Substrates will need to be identified in stressed cells. Parkin binds to ...

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Parkin Company PJSC (“Parkin” or the “Company”), the largest provider of paid public parking facilities and services in Dubai, today announces its planned dividend payment for the first half (“H1” or ...

Parkin Company PJSC (“Parkin”), the largest provider of paid public parking facilities and services in Dubai, has today entered into a Memorandum of Understanding (“MoU”) with Skyports ...

Meteorologist Jason Parkin first joined the KCCI 8 News team in 1998 and later returned in May 2016. Jason previously worked at WHO-TV and KCWI until it was sold to WOI. He has also worked at ...

Assistant manager Steve Parkin expects changes to be made to the Wrexham team for Tuesday’s EFL Trophy match against Wolves. That could mean starting places for strikers Paul Mullin and Steven ...