A multiplex drug screening platform with cellular biosensors identifies antivirals against 40 diverse viruses simultaneously.

"Inhibiting methyltransferase required using a non-conventional RNA substrate ... there were clear advantages to looking beyond protease inhibitors. Tuschl suspected that viruses would be less ...

Scientists have has pioneered antivirals targeting viral methyltransferases, offering a new strategy for treating RNA and DNA ...

"Inhibiting methyltransferase required using a non-conventional RNA substrate adding a new ... were clear advantages to looking beyond protease inhibitors. Tuschl suspected that viruses would ...

Treatment-experienced (genotype 1): treat for 16 weeks if previously treated with an NS5A inhibitor (without prior NS3/4A protease inhibitor ... of concomitant CYP450 substrates with a narrow ...

It is a serine protease that converts the zymogen plasminogen ... directly affect the permeability of the BBB. Recently, a new substrate that is activated by tPA was identified — PDGF-CC ...

Kinases are specialized enzymes that transfer phosphate groups from ATP to a substrate. The most often studied ... Cell lysates are prepared using M-Per lysis buffer with protease and phosphatase ...