Numerous changes have been detected in the liver of patients with psoriasis, including steatosis, periportal inflammation, fibrosis, necrosis, and cirrhosis (Pietrzak, Lecewicz-Torun ...
When psoriasis is refractory to topical therapy ... However, their use is limited by high levels of toxicity to the liver, kidneys and bone marrow, as well as by teratogenicity.