RNA splicing is a modification of the nascent ... splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and ...

Fungal tRNA Splicing as a Paradigm of RNA Repair – Intron-containing tRNAs are widespread in eukarya ... We recently solved a 2.2 Å crystal structure of the Candida Trl1 kinase domain in complex with ...

Furthermore, many other varieties of RNA have been found to have complex regulatory roles in cells. Thus, RNA molecules play numerous roles in both normal cellular processes and disease states.

To achieve faithful transcription, RNA polymerase (Pol) I, II and III rely on different sets of transcription factors, assembling into specific pre-initiation complexes (PICs) on cognate gene ...

Studying the RNA splicing process is very complex due to the chemical reactions and the molecular actors involved, such as RNA, proteins, ions, and water molecules. Thanks to modern molecular ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

Since inosine is interpreted as guanosine (G) by the cellular machinery, A-to-I editing can alter codons, splicing sites, and miRNA binding sites ... and structural biology approaches will provide a ...

If the nascent RNA is destroyed before it gets fully transcribed ... The team found that many variants linked to complex diseases are also associated with more unproductive splicing and decreased gene ...

For many people, RNA entered the consciousness during the race to develop a COVID vaccine. on Tuesday, three researchers who ...

Defects in RNA splicing or mutations can lead to a wide variety of diseases, ranging from metabolic disorders to cancer. A point mutation occurs when a single nucleotide is erroneously inserted ...

Notable achievements via X-ray crystallography include the first DNA catalyst, the human SF3B complex, and RNA helicase Aquarius. They also revealed the mechanism of splicing modulators (pladienolide, ...

June 24, 2024 — Researchers have harnessed a bacterial immune defense system, known as CRISPR, to efficiently and precisely control the process of RNA splicing ... view of the complex biological ...