Also, because they are single strands, RNA molecules don't form helices; rather, they fold into complex structures ... cell at a particular point in time. Ribosomes are the sites in a cell in ...

"We could target this interface, specifically between the RNAP, ribosome, and mRNA, with a compound that interferes with the recruitment or the stability of the complex." The team developed a ...

First, three initiation factor proteins (known as IF1, IF2, and IF3) bind to the small subunit of the ribosome. This preinitiation complex and a methionine-carrying tRNA then bind to the mRNA ...

Previous research in yeast showed that when translation slows down, only one tRNA is left in the ribosome, in the P site. When the A and E sites are empty for a long time, a complex called CCR4 ...

"Our working hypothesis is that by inserting one of its own proteins into the ribosome, the virus alters this key piece ...

We could target this interface, specifically between the RNAP, ribosome, and mRNA, with a compound that interferes with the recruitment or the stability of the complex." Adrien Chauvier ...

The rRNA molecules fold into complex secondary and tertiary structures, forming domains and motifs that are essential for ribosome function. The rRNA structures also provide binding sites for ...

His group has obtained detailed structural information on eukaryotic ribosomes, which are at 4.3 MDa significantly larger and more complex than their 2.6 MDa bacterial counterparts, by determining the ...

Clindamycin, lincomycin Lincosamides Bind to the 50S subunit of the ribosome (PTC), inhibiting ... of mycolyl–arabinogalactan–peptidoglycan complex in the cell wall, thus increasing cell ...

"We could target this interface, specifically between the RNAP, ribosome, and mRNA, with a compound that interferes with the recruitment or the stability of the complex." The team developed a ...