antagonist, currently in a phase 2 trial for the treatment of depression. NMDARs appear to be abnormally activated in depression. Whereas traditional antidepressants (such as selective serotonin ...

Serotonin antagonists, specifically cyproheptadine, have been used, but the documented benefits are purely anecdotal. Serotonin syndrome, also known as serotonin toxicity, is an iatrogenic ...