The investigation of Staphylococcus aureus signal peptidase, development of signal peptidase inhibitor HTS and search for new entities with signal peptidase inhibitory activity was carried out in ...

Then the SRP–signal peptide–ribosome complex binds to the ER membrane via an SRP receptor. The signal peptide is then inserted into the ER membrane via a signal peptide binding protein and the ...

Several new targets have been proposed, including proteins essential in the protein secretion pathway such as the type I signal peptidase (SPase), indispensable for the release of the signal ...