Single-cell sequencing applications have accelerated breakthroughs in life sciences, leading to significant impacts for disease treatments. Single-nuclei RNA-sequencing (snRNA-Seq) has been shown to ...

Researchers have combined two sequencing technologies in single cells to find new differences in mRNAs resulting from Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease.

“These nuclei could actually act as independent agents,” she added. Keenen, who has studied genome compaction and regulation in mononucleated cells, wanted to explore how the STB regulates its ...

A poor sample quality, for example containing a lot of dead cells, debris, and contamination from cell-free DNA and RNA, impairs sequencing results and also the costs of an experiment. Consequently, ...

Study design, alignment, SNPs, indels, CNVs, structural variants, annotation, visualization, network analysis, variant interpretation and classification ...

Researchers employed the high-throughput Illumina platform for single-nuclei RNA sequencing (snRNA-seq) alongside single-nuclei assay for transposase-accessible chromatin using sequencing (snATAC ...

A poor sample quality, for example containing a lot of dead cells, debris, and contamination from cell-free DNA and RNA, impairs sequencing results and also the costs of an experiment. Consequently, ...