We show here active clustering of TCR–MHC molecules at the immune synapse after interaction between aAPC and T cells. This multivalent system allows identification and stimulation of antigen ...

A key element of the T synapse is the specific relationship ... Not all antigens insert themselves into a cell membrane, however. How might the immune system take advantage of the B cell synapse ...

CAR T cell therapy revolutionizes oncology by using engineered T cells to target and eliminate cancer cells, improving ...

This study is an open-label, dose-escalation/expansion Phase I clinical trial (NCT05920876), aiming to assess the safety of ...

primarily found on the surface of T and NK cells. The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal in immune cell activation and adhesion ...

Seismic Therapeutic Inc. has provided preclinical data for S-4321, a novel dual-cell bidirectional (DcB) PD-1:FcγRIIb antibody being developed for the treatment of autoimmune disease. S-4321, a ...

New findings reveal how cancer manipulates immune pathways and highlight therapeutic strategies to unleash T-cells against even the most resistant tumors. Study: Cancer cells impair monocyte ...

The scientists were looking for "unconventional" and previously undiscovered ways the immune system naturally attacks tumours. What they found was a T-cell inside people's blood. This is an immune ...

Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells play a central role in immune responses against intracellular pathogens and tumors. CTLs and NK cells kill by forming a stereotyped ...