In the current analysis, 814 consecutive patients underwent TPMT genotyping and received a 4-week cycle of mercaptopurine. Concluding that TPMT genotype has a significant effect on response to ...

Economic evaluations of TPMT testing were identified from a systematic literature review of published studies. For the purpose of this study an economic evaluation was defined as: 'the comparative ...

In summary, genetic polymorphisms in TPMT play an important role in the processes of toxicity induced by 6-MP in children with ALL. Therefore, clinical guidelines have been developed to adjust the ...

The answer is enzymes. Enzymes in our bodies are catalysts that speed up reactions by helping to lower the activation energy needed to start a reaction. Each enzyme molecule has a special place called ...

pH is a measure of how acidic or alkaline a solution is. The diagram below shows what happens to an enzyme when denaturation occurs. Each enzyme has an optimum pH but it also has a working range ...

In an organism, the active site of each enzyme is a different shape. It is a perfect match to the shape of the substrate molecule, or molecules. This is essential to the enzyme being able to work.

Zhijian “James” Chen, a biochemist at the University of Texas Southwestern Medical Center, was awarded the 2024 Albert Lasker Basic Medical Research Award for the discovery of the cGAS enzyme that ...