But the researchers also made an unexpected discovery—that a certain subset of helper T cells, called Th1 cells, developed mitochondrial stress and DNA damage, and some of them died. The finding ...

By Pooja Toshniwal Paharia Study reveals that moderate fever temperatures (39°C) improve metabolism, proliferation, and ...

In a major potential step toward personalized therapy for atopic dermatitis, data suggest early, late, and no clinical ...

Autoimmune pancreatitis (AIP) is a clinical condition characterized by inflammation of the pancreas, caused by the body's ...

To enhance a particular T cell phenotype, culture conditions can be adjusted. For instance, Th1 needs IL-12, Th2 needs IL-4, Tregs need TGF-β1, and Th17 needs IL-6. > 95 % as determined by SEC-HPLC.

Rapa’s approach yields a T cell product with a phenotype with anti-cancer effects, including: promotion of Th1/Tc1 cytokine secretion while eliminating regulatory T cells; elimination of ...

This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for ...

Researchers found that natural killer T (NKT) cells influence whether the response generates protective antibodies that ...

Finally and counterintuitively, one type of helper T cells, important for warding off viruses, were stressed by the higher temps. Many of these Th1 cells died in response to the stress.

Improper self-antigen recognition by DCs and T-cell initiates, through release of specific cytokines (as described above), destructive Th1 or Th2 responses. RA, for example, is characterized by an ...

IL-18 stimulates natural killer (NK) cells, natural killer T (NKT) cells, and established Th1 cells to generate IL-3, IL-9, and IL-13 in the presence of IL-2. IL-18 promotes downstream signal ...