A pivotal study has provided unprecedented insights into the genetic architecture of sweet oranges, highlighting the critical ...

The pair had helped identify a still-unnamed disease, which they had tied to a particular gene and to a particular somatic mutation—a genetic change that had not been passed down from a parent and was ...

Mutations can be grouped into two main categories based on where they occur: somatic mutations and germ-line mutations. Somatic mutations take place in non-reproductive cells. Many kinds of ...

The result is a state called “somatic mosaicism,” in which two or more groups of cells in the same body possess different genetic compositions. In recent years, the discovery of conditions such as ...

St. Jude researchers reveal that moderate levels of mitochondrial DNA mutations boost leukemia growth by increasing metabolic ...

More information: GaRyoung Lee et al, Prediction of metabolites associated with somatic mutations in cancers by using genome-scale metabolic models and mutation data, Genome Biology (2024). DOI ...

Dr. Abdel-Wahab’s research focuses on the role of genomic alterations in the pathogenesis of hematopoietic malignancies. The Abdel-Wahab lab focuses on understanding and targeting the somatic ...