In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market; then, in the early 1990s the first-generation triazoles, fluconazole and itraconazole, became available.

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more effective drugs for human leishmaniasis, a parasitic disease that afflicts ...

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more ...

While occurrence and risks of azole antifungals in wastewater and meat industry have been studied, their presence in surface water and potential threats to water quality are underexplored. This ...

Fluconazole, a very safe and effective azole antifungal, requires a much higher dose in children (12 mg/kg/day) compared with adult patients. In addition, the neonatal field is exploring ...

The compound is a novel azole with activity about 100-fold more against Aspergillus fumigatus than voriconazole, the leading treatment currently. PC945 also reduced inflammation in the lung. PC945 ...

The findings, reported in Nature Communications, also solve a decades-long scientific puzzle that’s prevented drugmakers from successfully using azole antifungal drugs to treat visceral ...

The efficacy and safety of a combination therapy including caspofungin and another antifungal (either AMB or an azole) in a small patient group (17 patients, age range: 3–80 years) with ...

Scientists have identified strains of one of the world’s most dangerous fungal pathogens, already resistant to our most ...