These signalling systems operate beyond cell and tissue boundaries, but function as morphogens that are secreted from one cell or tissue type to activate surface receptors, signal transduction ...

A group of essential signaling molecules known as the Wnt pathway emerged early in the evolution of multicellular life.

Finally, pathways such as Wnt signaling are very complex and involve a number of different ligands, receptors and endogenous antagonists and the activation of distinct intracellular signaling ...

When he added the Wnt-coated beads to dishes in which embryonic stem cells were growing, the scientists could then watch individual cells that were close enough to a bead to receive a Wnt3a signal, ...

Scientists have identified how genetic variants influence the risk of neurological and psychiatric disorders, including ...

Boehringer is advancing the development of SZN-413 to prepare it for potential future clinical testing SZN-413 is a ...

In the first study, Bugacov and colleagues applied the genetic modification technique to study responses to different levels of Wnt pathway activation. The scientists found that low signaling ...

For many years, scientists have known that genetic variants, or differences in DNA code across people, play some role in ...

The regulation and remodeling of the tumor microenvironment (TME) are closely associated with how cancers typically progress ...

Dr. Gujral also works to develop better ways to screen potential cancer drugs. Noncanonical Wnt signaling pathway. Dr. Gujral’s lab explores how this pathway contributes to changes in cell state that ...

Aggregation of mutant forms of Huntingtin is the underlying feature of neurodegeneration observed in Huntington's disorder. In addition to neurons, cellular processes in non-neuronal cell types are ...

Sapience Therapeutics, Inc., a clinical-stage biotechnology company focused on the discovery and development of peptide therapeutics to address oncogenic and immune dysregulation that drive cancer, ...