南旧金山 - 专注于严重病毒性疾病的生物技术公司Assembly Biosciences, Inc. (NASDAQ:ASMB)公布了其慢性乙型肝炎病毒 (HBV)感染治疗药物候选ABI-4334的1b期研究中期结果。研究显示了良好的安全性和药代动力学特征,以及患者中显著的抗病毒活性。根据 InvestingPro 数据,该公司目前市值9356万美元,年初至今的市场表现强劲,回报率为49.58%。
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在其他近期新闻中,Assembly Biosciences与吉利德科学公司的合作取得了重大进展。两家公司修订了协议,Assembly Biosciences从吉利德科学公司获得了1000万美元的即时付款,用于他们共同的药物开发项目ABI-6250。此外,吉利德科学公司增持了Assembly Biosciences的股份,购买了940,499股普通股。
经典先天性肾上腺增生症是指一组遗传性代谢疾病,患者缺乏促进肾上腺激素生产的酶。大约95%的CAH病例是由导致21-羟化酶缺乏的突变引起的。在经典CAH中,这种酶的严重缺乏会导致肾上腺不能产生皮质醇,在大约75%的病例中,会导致醛固酮缺乏。如果不及时治疗,经典CAH可导致患者盐耗、脱水,甚至死亡。糖皮质激素是该疾病的标准疗法。
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