Some of the central molecular mechanisms that lead to hyperalgesia and allodynia after peripheral tissue injury involve the spinal dorsal horn transient receptor potential vanilloid 1 (TRPV1).
The neuraxial delivery of drugs has become a cornerstone in the management of pain, leveraging the pivotal roles of the dorsal root ganglion (DRG) and dorsal horn. These spinal structures are key in ...
The Doyle lab studies the pathophysiological and signaling mechanisms (e.g. glutamatergic signaling, neuroinflammation and nitro-oxidative stress) common to the development of cognitive impairment, ...
The presence of an initiating noxious event or a cause of immobilization. Continuing pain, allodynia, or hyperalgesia with which the pain is disproportionate to the inciting event. Evidence at ...
[79,91] Provoked pain includes allodynia, pain in response to a normally nonpainful stimulus, and hyperalgesia, an increased response to a normally painful stimulus. Unfortunately, unlike animal ...
Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve, hypoxia ...