Some of the central molecular mechanisms that lead to hyperalgesia and allodynia after peripheral tissue injury involve the spinal dorsal horn transient receptor potential vanilloid 1 (TRPV1).

Physical examination was difficult due to allodynia but no major abnormality was found. The team suspected opioid-induced hyperalgesia and decided to cut the patient's opioids by one-third initially.

The neuraxial delivery of drugs has become a cornerstone in the management of pain, leveraging the pivotal roles of the dorsal root ganglion (DRG) and dorsal horn. These spinal structures are key in ...

People who have negative expectations about a treatment actually experience more pain. Merve Karacaoglu discovered in her ...

nhs.net There remains uncertainty regarding the existence, mechanism and frequency of opioid-induced hyperalgesia (OIH). Literature to date has been dominated by the phenanthrene opioids, fentanyl and ...

While many people feel occasional physical pain, some people experience such a level of super-charged discomfort that it ...

uiowa.edu Potential peripheral mechanisms that might contribute to the development of visceral hypersensitivity and ultimately to the altered sensations that characterise functional gastrointestinal ...

The Doyle lab studies the pathophysiological and signaling mechanisms (e.g. glutamatergic signaling, neuroinflammation and nitro-oxidative stress) common to the development of cognitive impairment, ...

The following is a summary of “Efficacy and Safety of Pulsed Radiofrequency of Dorsal Root Ganglion in Elderly Patient ...

Like the rooster's crow at sunrise, COX-2 serves as part of the body's alarm clock for infection or injury, alerting it to systemic changes and helping it prepare to respond. Infectious diseases ...

Here's what causes chronic pain and how pain specialists use medications and treatments to help manage symptoms. The post How ...

Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve, hypoxia ...