Background/aims: Newborn resuscitation with pure oxygen may induce short- and long term pathological changes via oxidative stress. Oxygen can adversely affect all tissues of the body. We studied ...

Such findings suggest a temporal 'window of opportunity' for effective hyperoxic therapy. We found in a severe model of sepsis induced by cecal ligation and puncture in rats, a dose-related ...

A wish to alleviate tissue hypoxia underlies the common clinical use of hyperoxic ventilation in shock. Yet, this straightforward approach is met by skepticism that is based on the potential pro ...

Background and aims: We have recently shown that Dextromethorphan is neuroprotective against excitotoxic and hyperoxic-induced brain injury. Beside its antagonistic effect on the NMDA [N-methyl-D ...

BMC Genomics, 4;20(1):105. * co-first authors. *Undergraduate researcher Yuhao Zhang, Cristian Coarfa, Xiaoyu Dong, Weiwu Jiang, Brielle Hayward-Piatkovskyi, Jason Gleghorn, and Krithika Lingappan ...