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【前沿进展】焦保卫团队发现EGFR的分子胶降解剂
EGFR(epidermal growth factor receptor)在大多数肿瘤类型中高表达且驱动肿瘤的发生。然而,靶向EGFR的抑制剂仅在肺癌和结直肠癌中取得了良好的疗效,且仍会产生耐药性。EGFR抑制剂在其他多种肿瘤中均未见明显疗效,尤其在乳腺癌中收效甚微。基于此人们认为EGFR是 ...
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