阿尔茨海默病，俗称“老年痴呆”，但其影响远不止记忆力减退、思维能力下降。按照发展进程，阿尔兹海默病可分为4个阶段。示意图。重庆松山医院供图1.早期阶段：轻度认知障碍会经历轻微的记忆丧失，如忘记最近发生的事，或重复询问同样的问题。2.中期阶段：轻度至中 ...

而作为AD重要的遗传风险因素，APOE ε4也与CVD和其他类型痴呆风险增加有关。因此，以往大多数学者认为，血浆Hcy水平和APOE ε4之间可能存在协同作用。

The APOE region or locus is a segment of DNA with several genes in close apposition, including APOE. Its boundaries are not strictly defined, spanning a stretch between 0.2 and 10 Mb long. In 5’ to 3’ ...

Corder, E.H. et al. HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nature Med. 4, 1182–1184 (1998).

The study, published in Nature Medicine, also concludes that those individuals homozygous for APOE4 also develop the disease earlier than those with other variants of the APOE gene. These findings ...

Even in people genetically at risk of dementia, maintaining cardiorespiratory fitness is linked to better brain health later in life, new evidence suggests.

The strongest influence of cardiovascular risk and obesity on reduced brain volume is seen between 55 and 64 years of age in men and between 65 and 74 years in women.