Aims: To determine the maximum tolerated dose (MTD), safety and anti-tumor activity of afatinib combined with docetaxel in advanced cancer. Patients & methods: The MTD was determined from dose ...

The CHRYSALIS-2 study (NCT04077463) evaluated the combination of amivantamab (Rybrevant), an EGFR-MET bispecific antibody, ...

Afatinib (trade name: Giotrif) has been approved since April 2016 for the treatment of adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) of squamous histology who have ...

In the second generation came TKIs that were able to target more resistant mutations; molecules included afatinib. The third generation saw molecules like Osimertinib (Tagrisso), developed by ...

More studies are needed to elucidate the role of proton beam radiation therapy in HNSCC. The LUX-Head and Neck-1 (LHN) trial demonstrated that afatinib was associated with an improved PFS compared ...

The Innovation scorecard estimates report is produced by NICE and published by NHS Digital. The report shows the trend in prescribing of NICE recommended first-generation (gefitinib and erlotinib) and ...

and tightness of the chest • Afatinib is prescribed as a first-line treatment to treat non-small cell lung cancer, a specific type of lung cancer that has moved to nearby tissues or other body ...

Non-small-cell lung cancer (NSCLC) treatment has led to improved efficacy and compliance due to individual tailoring of the therapeutic options and the use of strategies based on both clinical ...

Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer TA61 27 May 2003 27 May 2003 Guidance on the use of drugs for early thrombolysis in the treatment of acute ...

We are working with Guy’s and St. Thomas’ NHS Foundation Trust to produce national standardised SACT regimen-specific consent forms. We want to support clinicians in ensuring all patients are fully ...

We are working with Guy’s and St. Thomas’ NHS Foundation Trust to produce national standardised SACT regimen-specific consent forms. We want to support clinicians in ensuring all patients are fully ...