Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing ...

Preclinical studies have shown AT-02 is able to bind to multiple amyloid types and can induce macrophage mediated amyloid phagocytosis and removal. The Food and Drug Administration has granted Orphan ...

As many as 23 different precursor proteins to the formation of amyloid have been described in man. These may deposit themselves in a fibrillar matrix within selected tissues. Fibrils are formed when ...

What did we learn during Summit’s bonus year of scientific discovery? Here are five sample projects with impactful results. Lighting the way to a new Alzheimer’s treatment Amyloid fibrils are protein ...

Transthyretin amyloid cardiomyopathy occurs when TTR tetramers dissociate into misfolded monomers that deposit as myocardium amyloid fibrils. Ex vivo studies found that acoramidis, a high-affinity TTR ...

According to Phipps, the drugs currently available to treat Alzheimer’s have only eased the symptoms rather than stop its ...

Crafting a unique and promising research hypothesis is a fundamental skill for any scientist. It can also be time consuming: ...

Engineers have developed AI frameworks to identify evidence-driven hypotheses that could advance biologically inspired materials.

EMA’s human medicine committee recommends marketing approval for acoramidis for treatment of transthyretin amyloid cardiomyopathy: Berlin Monday, December 16, 2024, 13:00 Hrs [I ...

Amyloidosis is a rare, multisystem disease that leads to deposition of misfolded proteins in various organs. This case report presents a patient with cancer with a rare diagnosis of diffuse ...