Background Cystic fibrosis (CF) lung disease is defined by large numbers of neutrophils and associated damaging products in the airway. Delayed neutrophil apoptosis is described in CF although it is ...

Eosinophil apoptosis was suppressed by Mcl-1 overexpression ... or DAPI staining was used to identify viable, apoptotic and necrotic bmEos. Western blotting was performed as described.1 8 9 Data ...

The accumulation of lipids in hepatocytes in nonalcoholic fatty liver disease (NAFLD) leads to an increase in reactive oxygen species and changes in the intracellular microenvironment, while ...

Is there ongoing apoptosis of ß-cells, and, if so, is this caused by aberrant genetic programming or something bad that invades the ß-cell's microenvironment? Type 2 diabetes is characterized as ...

By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...

Older than the Himalaya mountains, the mountain chain of the Western Ghats represents geomorphic features of immense importance with unique biophysical and ecological processes. The site’s high ...

Correspondence to Professor Ursula Fearon, Department of Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin D4, Ireland; fearonu{at}tcd.ie Objectives This ...