In vitro studies revealed that SPA deficiency reduced intracellular cholesterol accumulation and macrophage foam cell formation. Mechanistically, SPA deficiency dramatically downregulated the ...

A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

These lipid-laden macrophages cause immunosuppression ... Inhibiting the protein CD36 with sulfosuccinimidyl oleate (SSO) prevented the uptake of myelin debris, whereas blockade of the lipid ...

Figure 1. M1 and M2 macrophage polarization: Upon inflammatory (LPS, INFγ, TNFα) stimuli, macrophages are polarized into inflammatory M1 phenotype by activating NF-kB inflammatory pathway, ...

【导读】作为癌症中最常见的基因改变，超过一半的人类癌症具有导致转录失活的p53突变。然而，p53如何调节免疫景观以创造免疫逃逸的生态位，仍然难以捉摸。团队发现癌症干细胞（CSCs）建立了白细胞介素34（IL-34）编排的生态位，以促进p53灭活肝癌的 ...

Further, these macrophages demonstrate heightened mitochondrial mass and function ... Overall, these studies have underscored the potential of targeting CD36-mediated metabolic adaptations in immune ...

2024年9月9日，河南中医药大学李建生团队及武汉大学张好建团队在 Cell 子刊 Cell Reports Medicine 上发表了题为：Lipolysis engages CD36 to promote ZBP1-mediated necroptosis-impairing lung regeneration in COPD 的研究论文。

研究成果于 2024 年 9 月 24 日以“ Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation ” 为题，在线发表于 Immunity 杂志 ...

2024年9月24日， 中国科学技术大学生命科学学院魏海明团队在期刊《Immunity》上发表了题为“Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for ... 34信号可作为TP53突变癌症的潜在免疫疗法 IL-34或CD36的抗体阻断，导致显著的肿瘤生长受限。