A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

研究成果于 2024 年 9 月 24 日以“ Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation ” 为题，在线发表于 Immunity 杂志 ...

Background: The role of long non-coding RNAs (lncRNAs) in the invasion and metastasis of gastric cancer remains largely unclear. Methods: Integrating transcriptome data from The Cancer Genome Atlas ...

Figure 1. M1 and M2 macrophage polarization: Upon inflammatory (LPS, INFγ, TNFα) stimuli, macrophages are polarized into inflammatory M1 phenotype by activating NF-kB inflammatory pathway, ...

2024年9月9日，河南中医药大学李建生团队及武汉大学张好建团队在 Cell 子刊 Cell Reports Medicine 上发表了题为：Lipolysis engages CD36 to promote ZBP1-mediated necroptosis-impairing lung regeneration in COPD 的研究论文。

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ER-phagy, a selective form of autophagic ...

Here, we report the presence of multinucleated giant cells (MGC) – a type of macrophages – in tumors from patients with HNSCC, which are associated with a favorable prognosis in treatment-naive and ...

Supplemental Figure 5. Confirmation of unbiasedly identified cell cluster identities. Seurat generated violin plots of genes associated with distinct cell populations including mature B cells, pDCs, ...

These lipid-laden macrophages cause immunosuppression ... Inhibiting the protein CD36 with sulfosuccinimidyl oleate (SSO) prevented the uptake of myelin debris, whereas blockade of the lipid ...