A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

研究成果于 2024 年 9 月 24 日以“ Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation ” 为题，在线发表于 Immunity 杂志 ...

Further, these macrophages demonstrate heightened mitochondrial mass and function ... Overall, these studies have underscored the potential of targeting CD36-mediated metabolic adaptations in immune ...

Figure 1. M1 and M2 macrophage polarization: Upon inflammatory (LPS, INFγ, TNFα) stimuli, macrophages are polarized into inflammatory M1 phenotype by activating NF-kB inflammatory pathway, ...

2024年9月9日，河南中医药大学李建生团队及武汉大学张好建团队在 Cell 子刊 Cell Reports Medicine 上发表了题为：Lipolysis engages CD36 to promote ZBP1-mediated necroptosis-impairing lung regeneration in COPD 的研究论文。

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ER-phagy, a selective form of autophagic ...

Here, we report the presence of multinucleated giant cells (MGC) – a type of macrophages – in tumors from patients with HNSCC, which are associated with a favorable prognosis in treatment-naive and ...

These lipid-laden macrophages cause immunosuppression ... Inhibiting the protein CD36 with sulfosuccinimidyl oleate (SSO) prevented the uptake of myelin debris, whereas blockade of the lipid ...

Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...

From the Centers of Inflammation, Translational, and Clinical Lung Research (Y. Shao, Y. Sun, Y.L., F.S., C.D., C.J., K.X., X.J., X.Y.), Temple University, Lewis Katz ...

Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia (M.J.M., J.D.M., K.P.). Baker Department of Cardiometabolic ...