The best explored example of this phenomenon is the CYP2C19 polymorphism. In this table the most frequent alleles are presented that are important for the clinical practice [11,16]. Data on rare ...
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Omeprazole, the prototype drug of PPIs, is metabolized primarily by CYP2C19 to 5-hydroxyomeprazole. 5-hydroxyomeprazole is then transformed into 5-hydroxyomeprazole sulfone by CYP3A4. Omeprazole ...